Original Price 11.99GBP
SALE 50% OFF only £5.99 GBPP SW+SS Naturals Glutathione Soap
All Natural and Handcrafted Soap
Rich and moisturizing because it's 60% virgin coconut oil. Hypo-allergenic and safe for all skin types because of its all-natural ingredients.
Glutathione is a ubiquitous compound found in our bodies. Aside from its many ascribed biologic functions, it has also been implicated in skin lightening. Glutathione-induced inhibition of tyrosinase glycosylation blocks the maturation and transfer of tyrosinase from GERL (Golgi-endoplasmic reticulum-lysosome)-coated vesicles to the pre-melanosome. Other mechanisms of action proposed for glutathione include :
Direct inactivation of the enzyme tyrosinase by binding and chelating copper within the enzymeís active site.
Mediating the switch mechanism from eumelanogenesis to phaeomelanogenesis, as glutathione participates in the conversion of dopaquinone to pheomelanin. The observed differences in the glutathione and glutathione-related enzyme content between black and yellow (or red) skin provide evidence that the increase of glutathione-reductase activity in the environment of the melanocytes may stimulate the pigment cells to produce phaeomelanin instead of eumelanin pigment. As expected, the lowest levels of reduced glutathione (GSH) were found associated with eumelanin type pigmentation, whereas the highest ones were found in the skin with phaeomelanin producing melanocytes;
Quenching of free radicals and peroxides that contribute to tyrosinase activation and melanin formation;
Modulation of depigmenting abilities of melanocytotoxic agents.
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